In the Tissue Immunity and Immune Priming Lab, we are curious about understanding how an individual’s infection or microbial history shapes responses to subsequent insults and/or injury, with particular emphasis on tissue factors that mediate these outcomes. By carefully investigating these interactions, we aim to uncover the intricate relationships that dictate the immune response which can ultimately improve host defense or lead to increased susceptibility to subsequent infections.

To answer this multifaceted question, we employ various methodologies including different murine models, infection models, and multicolor flow cytometry techniques. Furthermore, we utilize other cutting-edge single cell approaches to meticulously dissect the contributions and roles of immune cells in shaping the pathogenesis of disease and outcomes to infections.

Ultimately, we believe that our research would enable us to contribute towards expanding the knowledge about immune mechanisms that influence responses during parasitic helminth infections and eventually leads to improving translational outcomes to infections in humans and animals